AT GC TA AT CG ATCGATCGATCGATCGATCG GCTAGCTAGCTAGCTAGCTA Met-Ala-Gly-Pro-Ser-Leu-Val-Ile TTAGGCAATCGTTACGGACC Pro-His-Trp-Cys-Gln-Arg-Lys 5'—ATCGGCTAGCTTAACGGATCCTTAG—3' 3'—TAGCCGATCGAATTGCCTAGGAATC—5' AUGCCGUACGAUUCCGGA
🏆 Winner — Best Architectural Design · Google All Things Agentic Hackathon ($180,000 prize pool · 12,260 participants) →
The Swiss Foundation of the Helixstreet Conglomerate

Where life, code, and cryptographic truth meet.

helixstreet.foundation is the Swiss foundation and public-good governance arm of the Helixstreet ecosystem — stewarding our A+ Polkadot validators (/1 & /2), open-source genomic & proteomic infrastructure on helixstreet.io, and our award-winning autonomous Google Cloud agent fleet on helixstreet.ai.

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Google Cloud × Devpost Winner · $180,000 Prize Pool · 12,260 Participants

Best Architectural Design: Helixstreet — Autonomous Genomic Fleet

Competing in one of the largest AI agent hackathons ever held ($180,000 USD prize pool across 12,260 participants), Helixstreet won Best Architectural Design under Track: The Fortified Enterprise Fleet. Built natively on Google Cloud Platform (GCP) — combining Google ADK, Vertex AI (Gemini 3.5 Flash), Gemma 4 31B, Google DeepVariant on Cloud Batch, Cloud Run, Eventarc, Cloud Storage, Firestore, BigQuery (1000 Genomes), Model Armor, Cloud DLP, Secret Manager, and Cloud Trace, while also evaluating NVIDIA Nemotron (Nemotron-3 Nano 30B / Super 120B) and NVIDIA Clara Parabricks as an NVIDIA Inception member.

▶ Official 4-Minute Unedited Demo · YouTube Watch on YouTube ↗
Live Production Fleet Command Center

dashboard.helixstreet.io

Inspect the live 5-agent ADK registry, annotated digital twins (NA12878 + CPIC pharmacogenomic alerts), salted Merkle Genome Vault (single-variant disclosure & IBS kinship proofs), and SHA-256 hash-chained audit ledger.

Launch Live Dashboard ↗ Architecture Deep-Dive → Devpost Winner ↗
One Unified Helixstreet Conglomerate

helixstreet.foundation

The Swiss Foundation near Zug. Stewards our A+ Polkadot validators (/1 & /2), open-source bioinformatics pallets, on-chain governance, and planetary genomic preservation.

Nominate our Polkadot validators →

helixstreet.io

The life-sciences Polkadot SDK chain and settlement layer for consented genomic & proteomic data, Icefish-style ZK eligibility proofs, XCM v5 interoperability, and 100.00% uptime public RPCs.

Visit helixstreet.io ↗

helixstreet.ai

The Sovereign Genomic Digital Twin and award-winning autonomous 5-agent genomic fleet running inside your own Google Cloud perimeter on Vertex AI & DeepVariant.

Visit helixstreet.ai ↗
Why Helixstreet

Boundless biological vision. Relentless engineering execution.

As the foundation arm of the Helixstreet conglomerate, every validator we operate and every protocol we fund serves a single unified vision across Earth and beyond.

🌍

01 · The Grand Vision: Elevate Life on Earth & Carry It to Mars

Our long-horizon mission is to advance all forms of life and health, enhance human biology, and cryptographically preserve the genomic blueprints of Earth's species as humanity expands toward Mars. By sealing genomes in salted Merkle trees and SHA-256 ledgers, altering a single base pair changes the root hash — giving us mathematical, tamper-evident proof of authentic, original life. NO LIMITS AT THE FRONTIER OF AI, GENOMICS & PROTEOMICS.

⚡

02 · Relentless Execution — Proven in Code, Not Noise

We are measured by systems in production: winner of Best Architectural Design in Google's All Things Agentic Hackathon ($180,000 prize pool · 12,260 participants), Polkadot validators consistently graded A+ with top-tier slot inclusion and era performance, and public RPC nodes delivering 100.00% availability at the lowest latencies on the network. WE DELIVER REAL RESULTS — NOT LINKEDIN AND TWITTER NOISE. WE DELIVER.

🤖

03 · AI-Native Architecture & Radical Lean Speed

A focused, senior engineering core amplified by a governed fleet of autonomous AI agents. No bloated committees, no performative roadmaps, and zero organizational drag — WE DO NOT OVERTHINK. WE JUST DO.

What we focus on

Three currents, one stream.

Life sciences grounded in biology. Decentralized infrastructure that returns control to patients and researchers. AI that accelerates discovery without flattening the human story.

Life sciences

Genomics, drug development, clinical trials, and preventive care — with patient experience and biological nuance treated as first-class data.

Decentralized infrastructure

Blockchain-based records, supply-chain provenance, and community governance that replace gatekeepers with auditable, patient-owned systems.

AI & language models

Large language models applied to genomics and biomedicine — to read DNA at scale, surface disease associations, and accelerate therapies.

Working groups

Six domains where we're moving first.

Each working group is an open collective of researchers, clinicians, developers, and community members building toward a specific, concrete outcome.

01

Patient dossier

Decentralized medical records that give patients real control of their history and let care teams access current, accurate information in real time.

02

Drug production control

An immutable record of every drug's journey — reducing counterfeiting, enabling recalls, and making the pharmaceutical supply chain trustworthy by default.

03

Drug logistics

Transparent tracking of stock levels and movements across the supply chain, so shortages are caught early and inventory flows where it's needed.

04

Drug development

Blockchain-coordinated clinical trials: faster recruitment, shared data in real time, and expedited regulatory paths — without compromising patient consent.

05

Patient-centered drug rating

A secure place for patients to share experiences with specific drugs — turning individual stories into rigorous signal on efficacy and side effects.

06

Genomics

Personal genomic data, personally controlled — opening the door to research consent at the individual level and truly personalized care.

The Foundation in Numbers

Swiss stewardship with a planetary & interplanetary horizon.

Registered near Zug, Switzerland, helixstreet.foundation is the public-good and validator arm of the Helixstreet conglomerate — operating A+ Polkadot validators, stewarding open-source genomic & proteomic infrastructure, and cryptographically preserving Earth's biological heritage.

A+
Polkadot Validator Grade (turboflakes ONE-T · 0 slashes)
12,260
Participants in Google's $180k Agentic Hackathon (Best Architecture Winner)
100%
Public Polkadot & Kusama RPC Availability
Earth→Mars
Cryptographically Hash-Saved Genomes & Proof of Original Life
Engineering & Research Notes

Notes from the frontier.

Architecture notes, validator telemetry, and research briefs across helixstreet.io and helixstreet.ai.

Google Award Winner · 2026

Helixstreet — Autonomous Genomic Fleet Architecture

How our five-agent ADK fleet (Gemma 4 31B + Gemini 3.5 Flash + DeepVariant on Cloud Batch + Merkle Genome Vault) won Best Architectural Design out of 12,260 participants.

Read architecture note on helixstreet.io →
Validator & RPC Infrastructure · 2026

A+ Polkadot Validators & 100.00% Uptime Public RPCs

Live telemetry, stash addresses for helixstreet.foundation/1 and /2, and why on-chain nomination loyalty is permanently remembered.

View live telemetry on helixstreet.io →
Cryptography & Genomics · 2026

Why DNA Is for Provenance & Original-Life Proofs, Not Sybil ID

How salted Merkle trees and Icefish-style ZK circuits prove authentic biological genomes and cohort eligibility without putting raw DNA on-chain.

Read the research note on helixstreet.io →

Nominate our validators. Build with the Helixstreet ecosystem.

Every nomination on Polkadot is permanently recorded on-chain — we remember who nominated us in case of a future ICO, and delegators who help push our additional helixstreet.foundation nodes into the active set provide critical leverage that will be specially remembered.